Drug-DNA Interactions: Structures and Spectra (Methods of Biochemical Analysis)

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9780471786269: Drug-DNA Interactions: Structures and Spectra (Methods of Biochemical Analysis)
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Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.

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From the Back Cover:

ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNAINTERACTIONS.

This informative guide is a thorough source of information onthe structural basis of drug-DNA interactions and their underlyingempirical evidence. It helps readers understand the underlyingmechanisms of the interactions, thus expediting research and aidingin the more efficient design of new and more effective drugs withlesser side effects. With a wealth of information gleaned fromdiverse studies and combined in a logical, practical format,Drug-DNA Interactions: Structures and Spectra:

  • Describes what types of structural information can be obtainedusing particular techniques
  • Classified structural and spectroscopic studies of drug-DNAadducts first by bonding types and then by the structure type ofthe drug
  • Covers intercalating drugs, groove-binding drugs,covalent-bonding drugs, strand-breaking drugs, and metal-containingdrugs
  • Focuses on structural and bonding information obtained byusing physico-chemical methods (such as X-ray crystallography, NMRspectroscopy, and molecular modeling), and optical spectroscopy(such as UV-Visible absorption, fluorescence, circular dichroism(CD), flow linear dichroism (FLD), and infrared (IR) and Ramanspectroscopy)

This is a hands-on reference for professionals in pharmaceuticalindustries and academia, pharmacologists, organic chemists,biochemists, and bioanalytical chemists. It also helps students inchemistry, biochemistry, and pharmacology understand the complexdrug-DNA interactions that could pave the way for tomorrow'sbreakthrough therapies.

About the Author:

Kazuo Nakamoto pioneered the use of metal isotopes toelucidate the involvement of metals in low-frequency vibrations inmetallic complexes and was among the first to use matrix isolationtechniques to prepare and characterize unstable specie. He is theauthor of Infrared and Raman Spectra of Inorganic and Coordinationcompounds, Fifth Edition (Wiley).

Masamichi Tsuboi studies DNA and RNA structures, drug-DNAinteraction, protein conformation, protein-nucleic acidrecognition, and virus structure using a variety of physicochemicaland biomedical techniques including X-ray diffraction, UV-Visible,IR/Raman , and NMR spectroscopy.

Gary D. Strahan uses physico-chemical techniques tounderstand biological systems relevant to pharmaceutical discoveryand agricultural and natural product analyses. His work hasemphasized spectroscopic methods, NMR, and computational modelingto determine the structures and properties of multistranded DNA,drug-DNA complexes, carbohydrates, and other biomolecules, as wellas metabonomic and chemometric studies.

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Book Description John Wiley and Sons Ltd, United Kingdom, 2008. Hardback. Condition: New. Language: English. Brand new Book. Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra , the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy. Seller Inventory # BTE9780471786269

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