Synopsis
The first book to present an integrated account of the role of iron in microbial pathogenicity and in clinical infection. Describes advances in biochemistry, microbiology, molecular genetics, and clinical science and identifies gaps in present knowledge. Encompasses bacterial, fungal, and protozoal pathogens and discusses recent discoveries that show the importance of iron uptake mechanisms to malignant and other rapidly proliferating cells. Considers the significance of recent developments to the design and use of new vaccines and to the therapeutic measures used in treating infections.
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From the Back Cover
Second Edition Iron and Infection Molecular, Physiological and Clinical Aspects Edited by J J Bullen University of Miami School of Medicine, USA, and E Griffiths World Health Organization, Geneva, Switzerland This revised edition covers major new advances made during the past decade on the role of iron in infection. These issues are of fundamental importance for understanding bacterial pathogenesis and resistance to infection, and are particularly relevant to present day circumstances in view of the progressive failure of antibiotics to control clinical infections. Topics covered are:
* Iron in biological systems
* Iron proteins
* The iron uptake systems of pathogenic organisms
* Iron as a regulatory signal
* Molecular genetics of iron transport as a component of virulence
* Iron and the immune system
* Iron binding proteins and host defence
* Clinical and physiological aspects
* Future prospects
Sepsis is a global problem which requires urgent investigation, and this second edition of Iron and Infection will be essential reading for clinical microbiologists and infectious disease specialists.
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Iron and Infection: Molecular, Physiological and Clinical Aspects
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Iron and Infection
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