Immunological and Infectious Diseases of the Peripheral Nerves - Softcover

Latov, N.; Wokke, John H. J.; Kelly, John J.

Softcover

ISBN 10: 0521159431 ISBN 13: 9780521159432

Publisher: Cambridge University Press, 2011

Synopsis

This is the first book dedicated to peripheral neuropathies of immune or infectious origin, which are now known to comprise a substantial proportion of disorders of the peripheral nerves. Many of the most important advances in the field were made by contributors to this volume. There are four sections, dealing with biology and epidemiology, patient evaluation, specific clinical syndromes known to be of infectious or immunologic origin, and therapy and management, including rehabilitation. Neurologists will welcome this comprehensive review of the field, which provides an authoritative overview of the pathogenesis, diagnosis and treatment of infectious and immune mediated neuropathies.

About this title

Book Description

The first book dedicated to peripheral neuropathies of immune or infectious origin, which are now known to comprise a substantial proportion of disorders of the peripheral nerves. Neurologists will welcome this comprehensive review of the field, which provides an authoritative overview of the pathogenesis, diagnosis and treatment of infectious and immune mediated neuropathies. It is directly relevant to the everyday management of patients, and will also meet the needs of the basic immunological researcher seeking a general overview.

From The New England Journal of Medicine

For much of their length, peripheral nerves are protected against the immune system by tight capillary endothelial junctions and perineurium. However, this protection is only relative. Lymphocytes, immunoglobulins, complement components, viruses, and toxins can gain access to motor nerves at their termination in skeletal muscle and to sensory nerves at the level of the dorsal-root ganglion. Such access can be a recipe for trouble, since peripheral nerves contain molecules that very suitably serve as autoantigens, such as myelin-specific lipids and proteins, and microglia-like cells that can present antigens to lymphocytes. Immune-mediated damage to the peripheral nervous system may occur in isolation, as in the Guillain-Barre syndrome, or as a component of a multisystem disorder, as in periarteritis nodosa. Immune damage in a nerve can be set in motion by an infection (e.g., lepromatous leprosy or Lyme disease), a neoplasm (e.g., the Lambert-Eaton myasthenic syndrome), or a connective-tissue disorder (e.g., rheumatoid arthritis).

The clinical presentations of immune-mediated peripheral nervous system disorders include symmetric distal polyneuropathy, selective involvement of one or more peripheral nerves, and pure dysfunctions of autonomic nerves or neuromuscular junctions. Diagnosis can be straightforward. For example, polyneuropathy that is rapidly progressive, is symmetric, and involves motor nerves more than sensory nerves in an otherwise healthy person is likely to be the Guillain-Barre syndrome; mononeuropathy multiplex in a person with evidence of renal and pulmonary involvement is often due to vasculitis. Measurements of nerve conduction velocity serve as a helpful extension of the clinical examination, making it possible to distinguish between demyelinative disorders and axonal disorders. Serologic studies (e.g., titers of antibodies in Lyme disease and human immunodeficiency virus infection) are often invaluable in making a specific diagnosis, as is histologic detection of amyloid or necrotizing arteritis.

Immunological and Infectious Diseases of the Peripheral Nerves is a valuable resource for clinicians involved in the diagnosis of neuromuscular disorders and care of patients with these diseases. The chapters are by experts and have been carefully and consistently formulated to cover the clinical, pathophysiologic, and therapeutic aspects of essentially all the known immunologic and infectious diseases affecting the peripheral nervous system. Despite the many authors, there is very little redundancy. The illustrations are, in general, well chosen, though the reproduction of histologic figures suffers somewhat from the paper stock and the lack of color. The chapters are well referenced with key articles, which in general were published through 1996 or the beginning of 1997. The book provides a well-structured appreciation of this group of peripheral nerve disorders. At least in my case, the opportunity to read through the book is likely to translate into a greater capacity to diagnose and manage illness in my patients.

Reviewed by David Pleasure, M.D.

About this edition

• Publisher: Cambridge University Press
• Publication date: 2011
• ISBN 10: 0521159431
• ISBN 13: 9780521159432
• Binding: Paperback
• Edition number: 1
• Number of pages: 454