RNA Interference Technology: From Basic Science to Drug Development - Softcover

Softcover

ISBN 10: 0521205174 ISBN 13: 9780521205177

Publisher: Cambridge University Press, 2011

Synopsis

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.

About this title

Book Description

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. In this 2005 overview, the basic concepts of RNAi biology are discussed, as well as the current and potential applications, providing an invaluable reference for all those who need to understand this emerging technology.

Review

"This book provides a window to the exciting new RNA interference revoluton with special emphasis on applications for biotechnology. It will provide up-to-date background for academic and industry researchers seeking to make use of this powerful research tool." Judy Lieberman, Havard Medical School

"A comprehensive treatise on RNA intereference has long been needed. That need has now been filled with this book, which placed RNAi and its potential squarely in the context of the post-human genome era. The successful juxtaposition of the many aspects of RNAi biology and technology should serve to stimulate creative though across the many diverse disciplines affected by the RNAi revolution." Ronald K. Scheule

"Only six years ago Fire and Mello discovered RNAi, as a funny effect in little worms. Now the whole world wants to know about it. In this book Krishnarao Appasani gets an all-star crowd of specialists to introduce RNAi: its history, biology, application in genomics research, and possible therapeutic use. Warmly recommended." Ronald Plasterk, Hubrecht Laboratories

"This extensive collection of timely articles brings us up to date on the current research on RNAi, its science and applications. It is a must-read to learn about current status of the art. This is a rapidly advancing field and it is useful for the newcomer both in academia and in industry to obtain a panoramic view and put the current literature in perspective." Robert Weinmann, Bristol-Myers Squibb

"This new book is very comprehensive, in many ways picking up where Hannon's RNAi manual leaves off. A good companion to Hannon." Frank Slack, Yale University

"This book is very timely. The chapters on the basics of RNAi, siRNA and miRNAs are an excellent summary of the recent origins of this topic, and the various sections dealing with RNAi technology provide comprehensive background material. I am sure that, even with the rapid progress in RNAi, this book will be useful for both newcomers to the field wishing to get an overview and experienced researchers looking for a summary of published information." David Baulcombe, The Sainsbury Laboratory

"The book...is an extraordinary effort to draw together the current knowledge in this field...Each section stands on its own merit and all chapters within each section are authored by leading authorities providing well written and excellent information on all topics...This book is an excellent snap-shot of the technology and its applications at this point in time and, as such, is highly recommended." - Canadian Journal of Medical Laboratory Science, Alan McNabb, BSc, ART

Edition details

• Publisher: Cambridge University Press
• Publication date: 2011
• Language: English
• ISBN 10: 0521205174
• ISBN 13: 9780521205177
• Binding: Paperback
• Number of pages: 546
• Editor: Appasani Krishnarao