Drug Resistance in Cancer: Mechanisms and Models - Hardcover

Goldie, James H.; Coldman, Andrew J.

Hardcover

ISBN 10: 0521482739 ISBN 13: 9780521482738

Publisher: Cambridge University Press, 1998

Synopsis

Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

About this title

Book Description

Drug resistance in cancer, whereby a proportion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. However, a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces which shape tumour growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context.

Review

'However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.' V. Spataro, Annals of Oncology

'... required reading for all trainees in oncology.' Paul P. Carbone, Oncology

Edition details

• Publisher: Cambridge University Press
• Publication date: 1998
• ISBN 10: 0521482739
• ISBN 13: 9780521482738
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 256