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Synopsis
The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
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Book Description
The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This text brings together basic aspects of the regulation of MHC antigens with important clinical applications.
Review
"...provides a useful review of MHC molecular and cellular biology and relates these findings to viral, oncological, and autoimmune diseases...for individuals interested in MHC biology in health and in disease, this book provides a timely and up-to-date review." Alice Gottlieb, The Lancet
"This book is a superb summary of the current understanding by some of the leading investigators." David R. Johnson, British Medical Journal
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- PublisherCambridge University Press
- Publication date1995
- ISBN 10 0521495784
- ISBN 13 9780521495783
- BindingHardcover
- Number of pages458
- EditorBlair G. Eric, Pringle Craig R., Maudsley D. John
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Modulation of MHC Antigen Expression and Disease
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Modulation of MHC Antigen Expression and Disease
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