Items related to Modulation of MHC Antigen Expression and Disease
The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
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The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This text brings together basic aspects of the regulation of MHC antigens with important clinical applications.
Review:
"...provides a useful review of MHC molecular and cellular biology and relates these findings to viral, oncological, and autoimmune diseases...for individuals interested in MHC biology in health and in disease, this book provides a timely and up-to-date review." Alice Gottlieb, The Lancet
"This book is a superb summary of the current understanding by some of the leading investigators." David R. Johnson, British Medical Journal
"This book is a superb summary of the current understanding by some of the leading investigators." David R. Johnson, British Medical Journal
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- PublisherCambridge University Press
- Publication date2005
- ISBN 10 0521499216
- ISBN 13 9780521499217
- BindingPaperback
- Edition number1
- Number of pages460
- EditorBlair G. Eric, Pringle Craig R., Maudsley D. John
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Modulation Of Mhc Antigen Expression And Disease
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The major histocompatibility complex (MHC) genes are involved in the immune system response to foreign agents like viruses and tumour cells. Alteration of MHC gene expression has profound effects in certain diseases. This book brings together basic aspects . Seller Inventory # 446937719
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Book Description Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - The immune system plays a key role in the bodys defence against foreign agents like viruses and tumour cells. The major histocompatibility complex (MHC) genes are involved in this defence. Alteration of the expression of MHC genes has profound effects on the outcome of certain diseases (such as cancers, viral infections and autoimmune diseases like diabetes). This book explores how altered MHC expression can be explained at the molecular level, and how normal MHC expression can be restored by gene therapy and immunotherapy. Seller Inventory # 9780521499217
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