Synopsis
This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.
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Book Description
This extensively up-dated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has seen significant advances since publication of the first edition. This practical and clear account will be of value to clinicians and researchers in oncology, genetics, surgery and general medicine, and to genetic counsellors
Review
'The book is an excellent and enjoyable to read. The amateur who is satisfied with certainly will drive more from it than the impartial professional seeking and challenge. For the majority of doctors and especially human cancer genetics the book succeeds as an example of the precept 'first do not harm'. Human Cancer Genetics book is a super textbook and should be in the library of every scientist interested in this subject.' Universitá degli Studi 'G. D'Annunzio' - Chieti
' ... oncology departments would do well to have a copy to hand ... it is clear that the authors are well informed ... Anyone with an interest in the incidence, significance, associations and management of a particular cancer predisposition will likely benefit from reading the relevant information contained in this book.' Human Genetics
'This book is highly recommended as a reference source to students, practitioners, and specialists. It will serve as an excellent starting point to discuss genetic disorders with patients.' Paul P. Carbone, Oncology
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