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The Evolution of Imperfection: The Science of Why We Aren’t and Can’t Be Perfect - Hardcover

Hurst, Laurence D.

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9780691247397: The Evolution of Imperfection: The Science of Why We Aren’t and Can’t Be Perfect
Hardcover
ISBN 10: 0691247390 ISBN 13: 9780691247397
Publisher: Princeton University Press, 2025

Synopsis

How understanding our genetic imperfections can change our view of evolution and enrich what it means to be human

If we start with the presumption that evolution is a constantly improving process, some aspects of our evolution just do not make sense. We have a high rate of genetic diseases, for example, and much of our DNA seems to be pointless. In The Evolution of Imperfection, Laurence Hurst explores our apparently rotten genetic luck.

Hurst, a leading authority on evolution and genetics, argues that our evolutionary imperfections proceed directly from two features: the difficulties of pregnancy and the fact that historically there are relatively few of us. In pregnancy, natural selection can favor chromosomes that kill embryos in species (including ours) that continuously receive resources from the mother. Most fertilized eggs don’t make it, and incompatibilities between the fetus and mother can lead to lethal disorders of pregnancy. The historically small population size enhances the role of chance, which in turn leads to both accumulation of unnecessary DNA and more mutation.

So what can save us? One answer may lie in genetic medicine, which has given us therapies that make killer conditions preventable and even curable.

Hurst suggests that our seeming imperfections could be the key to a new way to understand evolution itself. Looking at circumstances that seem to defy explanation, we might come to a richer understanding of how evolution really works, and what it means to be human.

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About the Author

Laurence D. Hurst is professor of evolutionary genetics in the Milner Centre for Evolution at the University of Bath. His research on how genetic systems evolve, and the application of this knowledge to medicine, has been recognized with national and international prizes and fellowships.

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Publisher
Princeton University Press
Publication date
2025
Language
English
ISBN 10 
0691247390
ISBN 13 
9780691247397
Binding
Hardcover
Number of pages
288
Rating
  • 3.77 out of 5 stars
    22 ratings by Goodreads