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After an introductory chapter that discusses the definitions, prevalence, and pathogenesis of perinatal tumors, the next 18 chapters systematically review neoplasms and tumorlike conditions of various organs. The writing is thorough, concise, and well referenced. Many illustrations and tables from the author's institution attest to an extensive personal experience in diagnostic pathology. A substantial portion of the book focuses on the practical pathological aspects of tumor diagnosis, including immunohistochemistry, electron microscopy, and cytogenetics. In addition, the discussion frequently emphasizes unusual clinical facets of these tumors that relate to their development during the perinatal period. For instance, the section on neuroblastoma, the most common perinatal malignant condition, comprehensively covers staging, pathological findings, cytogenetics, and prognostic data but emphasizes in addition clinical vignettes relevant to the perinatal occurrence of this tumor. These include the observations that congenital neuroblastomas occasionally mimic idiopathic hydrops fetalis; that antenatally (sonographically) diagnosed neuroblastomas are often unusual cystic tumors with a good prognosis; that fetal neuroblastomas may disseminate widely in the placenta within the fetal vasculature; and that fetal neuroblastomas have occasionally metastasized through placental anastomoses to a second fetus (a monozygous twin).
Although this concise textbook is intended largely as a handbook for pediatric pathologists, surgeons, and oncologists, its thorough coverage of the perinatal clinicopathological milieus should make it accessible and interesting to other physicians who care for fetuses and newborn babies.
Reviewed by David R. Genest, M.D.
Copyright © 1998 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
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