At the end of the last century Sigmund Freud abandoned his projected construction of a neurophysiologically based model of the mind and turned to the development of a psychological model, having recognized that the neurophysiology of his day was unequal to the task. Nonetheless, he predicted that a day would come when advances in knowledge of the functioning of the central nervous system would make possible the formulation of such a model. Over seventy years later we are still unable to propose a comprehensive theory, but there are many segments of our knowledge of the nervous system which can be related to behavior, and now many investigators work at the interface between neurophysiology and the behavioral sciences. The Hincks Memorial Lectures in 1969 reviewed some aspects of research and theory development, of demonstrable relevance to the field of mental health. Paul MacLean’s investigations and development of the concept of the limbic system have been seminal in the field of psychiatry and in related disciplines, combining rigor of investigation with a willingness to look at the broad implications of these findings. In addition, papers presented as a basis for panel discussions on “Memory” and “Sleep and Dreams,” are included in this volume. (from the Preface)
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