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Antisense Drug Technology: Principles: Strategies, and Applications - Hardcover

 
9780824705664: Antisense Drug Technology: Principles: Strategies, and Applications
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This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds.
Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes!

Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses
  • novel formulations of antisense drugs
  • practical methods to design effective isotype selective inhibitors
  • molecular mechanisms of antisense drugs
  • mRNA as a current biological template
  • modern postreceptor binding mechanisms
  • and more!
    With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.

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    Review:

    This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs. ... provides valuable insights into the great opportunities that are presented by this technology.
    ―Dr. Kees Fluiter, The University of Amsterdam, in ChemMedChem, Vol. 4, 2009

    This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies, and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition.
    ―Gary Evans, Industrial Research Ltd., in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 5

    "About this title" may belong to another edition of this title.

    • PublisherCRC Press
    • Publication date2001
    • ISBN 10 0824705661
    • ISBN 13 9780824705664
    • BindingHardcover
    • Edition number1
    • Number of pages948
    • EditorCrooke Stanley T.

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