Principles of Neural Science, Fourth Edition

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9780838577011: Principles of Neural Science, Fourth Edition

The most authoritative introduction to the brain, its structure, function, development, and control of behavior available today. Presents both a comprehensive summary of the state of the science and a full discussion of historical issues in the study of the brain. Neuroanatomy, cell and molecular mechanisms, mechanisms, of signaling, and development are thoroughly described in the context of the cognitive approaches to behavior. Thoroughly revised, with a new full-color art program, this text was re-designed to be more user friendly. Also featured is an expanded treatment of the development of the nervous system, the genetic basis of neurological and psychiatric diseases, the cognitive neuroscience of perception, and icon channel mechanisms

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Review:

"This is a simply wonderful book that makes accessible in one place all the details of how the neuron and brain work. The writing is clear. The drawings are elegant and educational. The book is a feast for both the eye and mind. The richness, the beauty, and the complexity of neuroscience is all captured in this superb book." "5 Stars!" (Doody's 2001-11-01)

From the Publisher:

CONTENTS
Contents. Preface. Acknowledgments. Contributors.

PART I: The Neurobiology of Behavior:

The Brain and Behavior. Nerve Cells and Behavior. Genes and Behavior.

PART II: Cell and Molecular Biology of the Neuron:

The Cytology of Neurons. Synthesis and Trafficking of Neuronal Protein. Ion Channels. Membrane Potential. Local Signaling: Passive Electrical Properties of the Neuron. Propagated Signaling: The Action Potential.

PART III: Elementary Interactions Between Neurons: Synaptic Transmission:

Overview of Synaptic Transmission. Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission. Synaptic Integration. Modulation of Synaptic Transmission: Second Messengers. Transmitter Release. Neurotransmitters. Diseases of Chemical Transmission at the Nerve-Muscle Synapse: Myasthenia Gravis.

PART IV: The Neural Basis of Cognition:

The Anatomical Organization of the Central Nervous System. The Functional Organization of Perception and Movement. Integration of Sensory and Motor Function: The Association Areas of the Cerebral Cortex and the Cognitive Capabilities of the Brain. From Nerve Cells to Cognition: The Internal Cellular Representation Required for Perception and Action.

PART V: Perception:

Coding of Sensory Information. The Bodily Senses. Touch. The Perception of Pain. Constructing the Visual Image. Visual Processing by the Retina. Central Visual Pathways. Perception of Motion, Depth, and Form. Color Vision. Hearing. Sensory Transduction in the Ear. Smell and Taste: The Chemical Senses.

PART VI: Movement:

The Organization of Movement. The Motor Unit and Muscle Action. Diseases of the Motor Unit. Spinal Reflexes. Locomotion. Voluntary Movement. The Control of Gaze. The Vestibular System. Posture. The Cerebellum. The Basal Ganglia.

PART VII: Arousal, Emotion, and Behavior Homeostasis:

Brain Stem, Reflexive Behavior, and the Cranial Nerves. Brain Stem Modulation of Sensation, Movement, and Consciousness. Seizures and Epilepsy. Sleep and Dreaming. Disorders of Sleep and Wakefulness. The Autonomic Nervous System and the Hypothalamus. Emotional States and Feelings. Motivational and Addictive States.

PART VIII: The Development of the Nervous System:

The Induction and Patterning of the Nervous System. The Generation and Survival of Nerve Cells. The Guidance of Axons to Their Targets.

The Formation and Regeneration of Synapses. Sensory Experience and the Fine-Tuning of Synaptic Connections. Sexual Differentiation of the Nervous System. Aging of the Brain and Dementia of the Alzheimer Type.

PART IX: Language, Thought, Mood, and Learning and Memory:

Language and the Aphasias. Disorders of Thought and Volition: Schizophrenia. Disorders of Mood: Depression, Mania, and Anxiety Disorders. Learning and Memory. Cellular Mechanisms of Learning and the

Biological Basis of Individuality.

Appendices:

(A) Current Flow in Neurons; (B) Ventricular Organization of Cerebrospinal Fluid: Blood-Brain Barrier, Brain Edema, and Hydrocephalus; (C) Circulation of the Brain; (D) Consciousness and the Neurobiology of the Twenty-First Century.

Index.

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