Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases; as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Disease is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: Atomic basis of protein-carbohydrate interactions, Structures and roles of Pseudomonas areuginosa lectins, Protein-carbohydrate interactions in enterobacterial infections, Retrocyclins: miniature lectins with potent antiviral activity, C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates, Synthetic carbohydrate-based anti-malarial vaccines and glycobiology. With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area.
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Carole A. Bewley is a Senior Investigator in the Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, USA (www.niddk.nih.gov). Research interests include studies of protein-carbohydrate recognition and discovery of novel lectins, especially as they pertain to blocking viral entry.Review:
....is a valuable source of knowledge in this area not only for graduate students but also for non-specialist readers.
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