Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases (Cancer Drug Discovery and Development) - Hardcover

Hardcover

ISBN 10: 089603710X ISBN 13: 9780896037106

Publisher: Humana, 2000

Synopsis

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

About this title

From the Back Cover

The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules.
Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Review

"Each chapter contains a well-referenced, clearly illustrated and up-to-date summary of the state of affairs including a discussion of the areas that are still open for further work. The volume provides a good read for both workers actively engaged in drug research as well as those working in the more fundamental areas of signaling and the cell cycle." - Cell Biology and Function

"...the range of topics included in this book is impressive....This volume works well on many levels. For graduate students struggling to assimilate the large body of signaling literature, the first half of the book offers what amounts to a comprehensive review of the most basic aspects of signal transduction. For experts, these same chapters serve as a point of departure for the second half, which deals with the emerging body of literature on how one can manipulate signaling pathways in the treatment of disease. It is the combination of basic and applied aspects of signal transduction that makes this book unique....the editor has done a remarkable job in selecting and assembling reviews from experts in signal transduction, and for presenting such a lucid discussion of this complex field." - Quarterly Review of Biology

"Each chapter is well referenced and stands alone as a comprehensive review in a specific area of signaling networks and cell-cycle control. In many cases the authors have highlighted several areas that are still open for further investigation, and have attempted to define the most likely molecular targets for pharmacological intervention...I would recommend this as a must have reference book, aimed mainly at an expert audience, which any good academic or biotechnological company library should have." - Cell Biology International

Edition details

• Publisher: Humana
• Publication date: 2000
• ISBN 10: 089603710X
• ISBN 13: 9780896037106
• Binding: Hardcover
• Language: English
• Number of pages: 592
• Editor: Gutkind J. Silvio