Gene Therapy of Cancer: Methods and Protocols (Methods in Molecular Medicine) - Hardcover

Hardcover

ISBN 10: 0896037142 ISBN 13: 9780896037144

Publisher: Humana Press, 2000

Synopsis

Wolfgang Walther and Ulrike Stein survey the rapidly evolving field of cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, the methods in this volume constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.

About this title

From the Back Cover

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. Gene Therapy of Cancer: Methods and Protocols, Second Edition fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Cutting edge and authoritative, Gene Therapy of Cancer: Methods and Protocols, Second Edition is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.

About the Author

Stein, Max-Delbruck-Center for Molecular Medicine, Berlin, Germany.

Edition details

• Publisher: Humana Press
• Publication date: 2000
• Language: English
• ISBN 10: 0896037142
• ISBN 13: 9780896037144
• Binding: Hardcover
• Edition number: 1
• Number of pages: 664
• Editor: Walther Wolfgang, Stein Ulrike