As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
"synopsis" may belong to another edition of this title.
Recent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those factors that are critical to the facilitation or suppression of these neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for many clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondrial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy.
Pioneering and richly insightful, Pathogenesis of Neurodegenerative Disorders offers a critical and integrative summary of the cutting-edge research findings that illuminate the common genetic, cellular, and molecular bases of many neurological disorders today that promise powerful new preventive and treatment approaches in future.
"...a timely collection of 12 papers authored by 26 experts...mechanisms combined with specific molecular genetic and environmental factors are responsible for the development of the diseases that are covered in a concise...manner in subsequent chapters...The chapter on "Trinucleotide Repeat Disorders" provides fascinating reading...The 12 chapters are balanced in length, are all well referenced, and provide a state of the art summary for those who are only tangentially involved in studying these disorders or treating patients suffering from any of them. On the other hand, for those whose main interest lies in research related to any of these diseases, it is a refreshing, well-written, and well-edited overview of a field that evolves and changes at unprecedented speed....With the help of well-known experts in the relevant fields, several basic pieces of the puzzle are provided that with the appropriate intellectual efforts can be sewn together. The result is the emergence of an overall view, the "Big Picture."...the overall value of the book is undeniable, and it is beyond doubt that it will serve as a major reference source for neurologists, neuropathologists, and residents training in the respective fields." - Modern Pathology
"A wide range of conditions and illnesses are covered, including ALS, muscular dystrophy, Parkinson's, Huntington's, Alzheimer's, Down's, stroke, and spinal cord trauma. Whole articles are devoted to neurogenetic mechanisms, oxidative processes, excitotoxicity, and apoptosis. From the viewpoint of a general clinical neurologist, the best feature of this book is that it is, for the most part, an understandable summary and update of the neuroscience that was not yet discovered a few years ago. The illustrations are of good quality...This book is good for a clinician because it broadens one's horizons and gives the clinician a better ability to help patients understand their problems. It would be good for a researcher or a graduate student because it summarizes what is being done in many fields." -Doody's Health Sciences Book Review Journal
"This handy pocket guide will be useful for many residents and clinicians, especially in those specialties that treat Alzheimer's disease. It is a worthy addition to departmental and hospital libraries and, predictably, will be used quite frequently." - The Canadian Journal of Neurological Sciences
"About this title" may belong to another edition of this title.
Shipping:
US$ 6.70
From United Kingdom to U.S.A.
Shipping:
US$ 3.99
Within U.S.A.
Seller: Books Puddle, New York, NY, U.S.A.
Condition: New. pp. 308. Seller Inventory # 26250865
Quantity: 1 available
Seller: Majestic Books, Hounslow, United Kingdom
Condition: NEW. pp. 308 Illus. Seller Inventory # 7629870
Quantity: 1 available
Seller: AwesomeBooks, Wallingford, United Kingdom
Hardcover. Condition: USED_VERYGOOD. Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience) This book is in very good condition and will be shipped within 24 hours of ordering. The cover may have some limited signs of wear but the pages are clean, intact and the spine remains undamaged. This book has clearly been well maintained and looked after thus far. Money back guarantee if you are not satisfied. See all our books here, order more than 1 book and get discounted shipping. Seller Inventory # 7719-9780896038387
Quantity: 1 available
Seller: Plurabelle Books Ltd, Cambridge, United Kingdom
Hardcover. Condition: Very Good. Series: Contemporary Neuroscience large format hardback with orange illustrated laminated boards, excellent condition, minimal library markings, very good indeed, almost as new Language: English. Seller Inventory # 159695
Quantity: 1 available
Seller: Bahamut Media, Reading, United Kingdom
Hardcover. Condition: USED_VERYGOOD. This book is in very good condition and will be shipped within 24 hours of ordering. The cover may have some limited signs of wear but the pages are clean, intact and the spine remains undamaged. This book has clearly been well maintained and looked after thus far. Money back guarantee if you are not satisfied. See all our books here, order more than 1 book and get discounted shipping. Seller Inventory # 6545-9780896038387
Quantity: 1 available
Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.
Condition: NEW. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability. Seller Inventory # ABTR-63714
Quantity: 5 available
Seller: Basi6 International, Irving, TX, U.S.A.
Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. Seller Inventory # ABEJUNE24-142573
Quantity: 13 available
Seller: Antiquariat Buchkauz, Herzogenburg, Austria
Gr. 8°, Hardcover. Condition: Gut. first Edition. 294 S. good condition Sprache: Englisch Gewicht in Gramm: 788. Seller Inventory # 355217
Quantity: 1 available
Seller: UK BOOKS STORE, London, LONDO, United Kingdom
Condition: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 7-12 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability. Seller Inventory # CB 9780896038387
Quantity: 13 available
Seller: Universal Store, Princeton Junction, NJ, U.S.A.
Condition: New. Brand New! . "This is an International Edition." Book is In New condition and ship within One Working Day Tracking Number Provided by Customer 12-24 In To Hour, Deliver by FedEx & Aramex, UPS, & USPS Act. Order can be delivered worldwide With In 8-14 Working day Delivery. Ship from India & United States. Seller Inventory # CBS34340
Quantity: 13 available