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Neurologic complications of systemic cancer and its treatment often present complex diagnostic and management problems, commonly have a great impact on quality of life, and are a major factor in the death of cancer patients. In Cancer Neurology in Clinical Practice, leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how these symptoms should be interpreted and evaluated. Organized by both symptom and type of cancer, the book carefully describes each diagnostic neurologic entity-from symptomatology, to diagnostic studies, to management and prognosis-and presents each major type of cancer in terms of its neurologic problems and how they should be handled. This dual organization allows physicians quickly to obtain neurologic guidance on either a diagnostic problem (e.g., confusion and delirium) or on the neurologic problems and treatments associated with a specific type of cancer (e.g., lung cancer). The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem.
Multidisciplinary and up-to-date, Cancer Neurology in Clinical Practice explains to the busy physician treating cancer patients all the latest findings in neuro-oncology that will help sharpen their differential diagnoses, diagnostic strategies, and treatment plans for those patients with neurologic symptoms and findings.
Dr. Schiff and his colleagues have conducted several dozen clinical trials assessing new treatments for glioblastoma, anaplastic gliomas, low-grade gliomas, brain lymphomas, brain metastases, and meningiomas. These trials have included treatment with new cytotoxic chemotherapy drugs, signal transduction inhibitors, radiation sensitizers, brachytherapy and radiosurgery, anti-angiogenesis agents, differentiation agents, monoclonal antibodies, and targeted immunotoxins. A second research focus is the cause of gliomas and brain lymphoma. Dr. Schiff has studied risk factors for the development of brain lymphoma in patients with intact immune systems, including the association between organ transplantation and the subsequent development of glioma. Spinal cord disease in cancer patients is another area of ongoing research, in particular the diagnostic role of MRI and the optimal management of metastatic spinal disease.
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