Items related to Therapeutic Targeting of RAS Mutant Cancers (Elements...

Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology) - Softcover

Stites, Edward C.

 
9781009073646: Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
Softcover
ISBN 10: 1009073648 ISBN 13: 9781009073646
Publisher: Cambridge University Press, 2022

Synopsis

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

"synopsis" may belong to another edition of this title.

Publisher
Cambridge University Press
Publication date
2022
Language
English
ISBN 10 
1009073648
ISBN 13 
9781009073646
Binding
Paperback
Edition number
1
Number of pages
38