Introduction to Randomized Controlled Clinical Trials (Chapman & Hall/CRC Texts in Statistical Science) - Hardcover

Matthews, John N.S.

Hardcover

ISBN 10: 1138469505 ISBN 13: 9781138469501

Publisher: Chapman and Hall/CRC, 2017

Synopsis

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as cross-over trials, cluster-randomized designs, and equivalence studies.

This latest edition features new and revised references, examples, exercises, and a new chapter dedicated to binary outcomes and survival analysis. It also presents numerous examples taken from the medical literature, contains exercises at the end of each chapter, and offers solutions in an appendix. The author uses Minitab and R software throughout the text for implementing the methods that are presented.

Comprehensive and accessible, Introduction to Randomized Controlled Clinical Trials is well-suited for those familiar with elementary statistical ideas and methods who want to further their knowledge of the subject.

About this edition

• Publisher: Chapman and Hall/CRC
• Publication date: 2017
• ISBN 10: 1138469505
• ISBN 13: 9781138469501
• Binding: Hardcover
• Edition number: 2
• Number of pages: 302