Genomic Approaches for Cross-Species Extrapolation in Toxicology - Hardcover

Hardcover

ISBN 10: 142004334X ISBN 13: 9781420043341

Publisher: CRC Press, 2006

Synopsis

The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from the experience of thirty-five scientists and professionals from diverse fields including environmental toxicology and chemistry, biomedical toxicology, molecular biology, genetics, physiology, bioinformatics, computer science, and statistics.

The book introduces genomic, transcriptomic, proteomic, and metabolomic technologies. It describes the advantages and challenges associated with these approaches compared to traditional methodologies, particularly from the perspective of cross-species extrapolation within human and environmental toxicology, and explores solutions that will facilitate the incorporation of these technologies into predictive toxicology. The book goes on to identify and prioritize species of animals that can serve as surrogates for environmental and human health in comparative toxicogenomic studies. The chapter authors elucidate similarities and differences among species, relate stressor-mediated responses to adverse outcomes, and extend this science into innovative approaches to risk assessment and regulatory decision-making.

About this edition

• Publisher: CRC Press
• Publication date: 2006
• ISBN 10: 142004334X
• ISBN 13: 9781420043341
• Binding: Hardcover
• Edition number: 1
• Number of pages: 216
• Editor: Benson William H., Di Giulio Richard T.