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Synopsis
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry.
While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping.
The common goals of experimental design―such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints―are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.
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About the Author
Valerii Fedorov, PhD, is Vice President of Predictive Analytics, Innovation at Quintiles.
Sergei Leonov, PhD, is a Senior Principal Scientist at AstraZeneca.
"About this title" may belong to another edition of this title.
- PublisherCRC Press
- Publication date2013
- ISBN 10 1439821518
- ISBN 13 9781439821510
- BindingHardcover
- LanguageEnglish
- Edition number1
- Number of pages402
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OPTIMAL DESIGN FOR NONLINEAR RESPONSE MODELS
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CRC Press, 2014
ISBN 10: 1439821518
ISBN 13: 9781439821510
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Hardback. Condition: Very Good. No Jacket. First edition. 1st 2014. Very good condition with no wrapper. Chapman & Hall/CRC Biostatistics Series. The theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. Blue glazed boards. Lower corners and base of spine bumped. Front edge of base of spine nicked. Small spot of surface paper loss to front cover. Text block slightly grubby. A few minor incidences of pen marks to margins. Hinges pulled. Packaged with care and promptly dispatched! Seller Inventory # 1820477
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Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Valerii Fedorov, PhD, is Vice President of Predictive Analytics, Innovation at Quintiles.Sergei Leonov, PhD, is a Senior Principal Scientist at AstraZeneca.Optimal Design for Nonlinear Response Models discuss. Seller Inventory # 595834567
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