Synopsis
The authors emphasize the functional role of the various signaling pat hways in memory, apoptosis and degeneration, depression, and drug depe ndence in both health and diseased states. By taking full advantage of the newfound ability to selectively remove, reduce, or enhance specif ic components of the signaling pathways, the investigators writing her e illuminate the varied signaling cascades, their crosstalk, and the m any possibilities for changes in gene expression underlying long-term changes in brain function. Cutting-edge and comprehensive, Cerebral Si gnal From First to Fourth Messengers advances our unders tanding of the mechanistic underpinnings of complex behavioral process es and clinically relevant brain diseases. A major contribution to the development of the novel pharmacotherapeutics targeting downstream ev ents in the cascade of second, third, and fourth messengers, it will s erve experimental and clinical neuroscientists as the best and most co mplete guide to neuronal signaling.
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