Summarizes the general principles and mechanisms involved in protein metallocenter assembly, describing the features in relation to proteins that reversibly bind metal ions or metal ions plus an additional compound or co-factor. Provides a mechanistic framework for understanding the process, and synthesizes from the literature of several disciplines the recent experimental findings on the various options available to the cell for controlling metal incorporation, possible reasons why the expression of the structural gene is not enough to obtain a functional metalloprotein, the roles of accessory proteins that facilitate metal incorporation, and other topics. Annotation copyright Book News, Inc. Portland, Or.
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