Cardiovascular Disease: Methods and Protocols, Vol. 1: Genetics (Methods in Molecular Medicine, Vol. 128)

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9781588295729: Cardiovascular Disease: Methods and Protocols, Vol. 1: Genetics (Methods in Molecular Medicine, Vol. 128)

Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.

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The primary care physician (PCP) is the front line of defense against cardiovascular disease, managing a patient's cardiovascular illness and coordinating care with a cardiologist. As such, the PCP needs to have on hand all the most recent information on the diagnosis, treatment, and prevention of common cardiac problems. In Cardiology in Family Practice: A Practical Guide, Steven Hollenberg, MD, and Tracy Walker, MD, undertake to provide primary care physicians with the latest medical and scientific knowledge they need to treat most of the preventive and acute cardiovascular problems they will encounter and to understand clearly when to refer patients to a cardiologist. Writing in an easy-to-read format-background, diagnosis, and disease management-and emphasizing practical techniques of evaluation and treatment, the authors explain the basic mechanisms underlying cardiovascular disease states and the treatment strategies that arise from them. Topics range from acute coronary syndromes, arrhythmias, and hyperlipidemia, to hypertension, pericardial diseases, valvular disease, and stable angina. Simple but clinically useful references point the inquiring physician to the most useful sources of additional information.
Concise and up to date, Cardiology in Family Practice: A Practical Guide offers a clear understanding of today's standard approaches to cardiovascular illnesses and a highly valuable resource when specific questions arise during the care of patients.

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"Second volume ... in its 22 chapters describes methods for comprehension of disease mechanism at the molecular level. ... Each chapter contains detailed protocols needed for each practical step in course of experimentation so that it may serve as a guide even for beginners. ... intended for undergraduate and graduate students, postdoctoral fellows, clinicians and basic researchers, who are entering new areas of cardiovascular research and/or designing new experiments. Many protocols could be applied in research of another diseases as well.” (Lubica Lacinová, General Physiology and Biophysics, January, 2007)

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