Local Control of Microvascular Perfusion (Colloquium Lectures on Integrated Systems Physiology) - Softcover

Hill, Michael; Davis, Michael

Softcover

ISBN 10: 1615044361 ISBN 13: 9781615044368

Publisher: Morgan & Claypool Life Sciences, 2012

Synopsis

Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.

Edition details

• Publisher: Morgan & Claypool Life Sciences
• Publication date: 2012
• Language: English
• ISBN 10: 1615044361
• ISBN 13: 9781615044368
• Binding: Paperback
• Number of pages: 144