Control of Potassium: Distribution, Excretion, and Extracellular Concentration (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease) - Softcover

Young, David B.

Softcover

ISBN 10: 1615045007 ISBN 13: 9781615045006

Publisher: Morgan & Claypool Life Sciences, 2013

Synopsis

Several physiological mechanisms act to regulate renal potassium excretion and distribution. Together they comprise an integrated control system that may be envisioned as being made up of several interacting negative feedback control mechanisms, all affecting removal of potassium from the extracellular fluid by renal excretion or transfer across cell membranes into or out of the intracellular compartment. The intent of this presentation is to describe the mechanisms of potassium regulation, beginning in Chapter 1 with an overview of the system, Chapter 2 with mechanisms that determine movement of potassium between the extracellular and intracellular compartments, in Chapter 3 focusing on renal tubular transport systems, and in Chapter 4 presenting the mechanisms of control of aldosterone secretion. Greatest emphasis will be on describing the integrated functions of the components, in Chapter 5, as they operate together in a system to regulate extracellular potassium concentration in response to commonly encountered challenges. In addition, interactions between potassium regulation and commonly used medications will be considered in Chapter 6, and in Chapter 7 the causes and treatment of dysregulation of potassium will be discussed.

Table of Contents: Preface / Introduction / Regulaton of Potassium Distribution / Potassium Transport in Segments of the Nephron / Regulation of Potassium Excretion / Control of Aldosterone Secretion / System Analysis of Potassium Regulation / Pharmacotherapeutics Interactions / Disorders of Potassium Control / References / Author Biography

About this title

About the Author

David B. Young was born in Pittsburgh, PA in 1945. He graduated from Shady Side Academy in Pittsburgh in 1963, completed his undergraduate study at the University of Colorado in 1967, earned the Ph.D. degree in Physiology from Indiana University in 1972, and then began a two year post-doctoral fellowship studying cardiovascular physiology with Arthur C. Guyton at the University of Mississippi Medical Center in Jackson, Mississippi. Dr. Young joined the faculty in the Department of Physiology and Biophysics at that institution in 1974 as an Instructor and rose in rank to become a Professor in 1980. He became Professor Emeritus in 2001. In 1970 he was awarded an NIH Individual Predoctoral Fellowship, an NIH Post-Doctoral Fellowship in1972, and an NIH Research Career Development Award in 1977. Throughout his career, Dr. Young's research concerning the control and cardiovascular effects of potassium, vascular disease, and hypertension was supported by several grants from the National Institutes of Health. He has published over 100 articles in peer-reviewed journals, contributed chapters to several books, and previously authored two books concerning his research findings related to cardiovascular physiology and the protective effects of potassium. Dr. Young served in numerous review and consulting positions, including Associate Editor, American Journal of Physiology: Regulatory, Integrative and Comparative Section from 1995-2001, Consultant, Steadman's Medical Dictionary, 27th and 28th editions, and Chairperson, NIH HL/NAHAS Special Study Section, January and July 1986. During his career he directed the training of seven doctoral students and numerous post-doctoral fellows. Also, he was awarded two patents for inventions related to artificial mechanical hearts. Currently, Dr. Young continues to publish and consult on topics related to his research interests in cardiovascular physiology, the cardiovascular protective effects of potassium, and regulation of potassium. Dr. Young has been married since 1965 to his wife, Susan. They have three adult children and three grandchildren, and divide their time between homes in Germantown, Tenessee and near Aspen, Colorado. His interests include outdoor sports and activities, traveling, and photography.

Edition details

• Publisher: Morgan & Claypool Life Sciences
• Publication date: 2013
• Language: English
• ISBN 10: 1615045007
• ISBN 13: 9781615045006
• Binding: Paperback
• Number of pages: 104