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Book Description Condition: New. Book is in NEW condition. 1.8. Seller Inventory # 1621824187-2-1
Book Description Condition: New. New! This book is in the same immaculate condition as when it was published 1.8. Seller Inventory # 353-1621824187-new
Book Description Condition: New. Seller Inventory # 46975668-n
Book Description Paperback. Condition: new. Paperback. In this postgenome era, the large number of mouse mutations available is revolutionizing biomedical research. Large-scale mutagenesis projects have resulted in the modification of thousands of mouse genes and, more recently, with CRISPR-Cas gene editing, generation of custom mutations is easier than ever. The interpretation of mutant phenotypes is critically important for understanding how changes in the genome result in changes in the phenotype. Complex phenotypes resulting from gene manipulation or spontaneous mutation, however, provide a huge analytic challenge. Where does one start with the analysis? How does one dissect the phenotype and begin to understand the molecular and developmental consequences of the genotype? How does one make the best use of the valuable resource that you have developed? Mouse Phenotypes: A Handbook of Mutation Analysis, Second Edition, provides a road map for such analysis. Advice and practical guidance are provided, starting with the planning stages of gene targeting, CRISPR-Cas gene editing, or mutagenesis experiments, through the complete analysis of complex phenotypes, including tips on breeding strategies, studying dominant mutations, and characterizing a mutant mouse with no apparent phenotypic abnormalities. A systematic approach to the analysis, complemented with simple protocols, will help users make a comprehensive assessment of a particular phenotype resulting from a mutation and determine the timing and likely causes of specific developmental failures. Investigators using the laboratory mouse in genetic studies designed to understand mammalian biology will benefit from the authors' experience and advice in analyzing mutant phenotypes. This book provides a road map for such analysis. Advice and practical guidance are provided, starting with the planning stages of gene targeting, CRISPR-Cas gene editing, or mutagenesis experiments, through the complete analysis of complex phenotypes, including tips on breeding strategies, studying dominant mutations, and characterizing a mutant mouse with no apparent phenotypic abnormalities. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9781621824183
Book Description paperback. Condition: New. Language: ENG. Seller Inventory # 9781621824183
Book Description Paperback. Condition: Brand New. 2nd lab edition. 306 pages. 8.90x10.30x1.00 inches. In Stock. Seller Inventory # x-1621824187
Book Description Condition: New. Seller Inventory # 46975668-n
Book Description Seller Inventory # STOCK17385441
Book Description Condition: New. Second edition "A laboratory manual"--Cover Includes bibliographical references and index. Seller Inventory # 26397662884
Book Description Condition: New. Seller Inventory # 398747003