High Throughput Screening Methods: Evolution and Refinement (Chemical Biology, Volume 1) - Hardcover

Hardcover

ISBN 10: 1782624716 ISBN 13: 9781782624714

Publisher: Royal Society of Chemistry, 2016

Synopsis

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success.
Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions.
This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

About this title

Book Description

This book highlights the changing role of high-throughput screening as it has moved from mainly an industrial process to a discovery tool used by many scientists to understand and validate biological systems. The main focus is how screening methods for small molecule discovery have evolved over the past couple of decades since the concept of high-throughput screening became a major part of drug discovery. Expert authors address past shortcomings and how advances in the field have tried to fix problems. The newest techniques are presented with any existing caveats or pitfalls that are known to provide chemical biologists with guidance on the application of these techniques, as well as what additional improvements might be possible in future.

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2016
• ISBN 10: 1782624716
• ISBN 13: 9781782624714
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 396
• Editor: Bittker Joshua A, Ross Nathan T