Looking at Ribozymes: Biology of Catalytic RNA (Biology: Nucleic Acids, 2) - Hardcover

 
9781786309778: Looking at Ribozymes: Biology of Catalytic RNA (Biology: Nucleic Acids, 2)
Hardcover
ISBN 10: 1786309777 ISBN 13: 9781786309778
Publisher: Wiley-ISTE, 2024

Synopsis

Behind the neologism “ribozymes” lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome.

At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly “proteocentric” vision, inherited from the dogma of molecular biology, to a more “nucleocentric” one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious.

Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life.

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About the Author

Benoīt Masquida is director of research at the French National Center for Scientific Research (CNRS) and carries out his research and teaching activities at the University of Strasbourg, France. He is the author of over 60 publications and is one of France’s leading specialists in ribozymes.

Fabrice Leclerc is a research fellow at the CNRS and conducts his research at the Paris-Saclay University, France. He has published numerous articles on RNA catalysis in ribozymes and their role in viroids and in the RNA world.

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Publisher
Wiley-ISTE
Publication date
2024
Language
English
ISBN 10 
1786309777
ISBN 13 
9781786309778
Binding
Hardcover
Edition number
1
Number of pages
192
Editor
Masquida Benoīt