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Cardiac resynchronization therapy (CRT) is one of the most exciting new advances in the treatment of chronic severe (NYHA symptom class) heart failure associated with dyssynchronous ventricular contraction that is refractory to medical treatment. In all randomized trials CR has resulted in improved NYHA symptom class, exercise capacity and quality of life in the majority of patients as compared to patients on optimal medical therapy including angiotensin converting enzyme inhibitor (ACE)/angiotensin receptor blocker inhibitor (ARB) and b adrenergic receptor blockers. These symptomatic benefits are mediated by "reverse remodeling" of the left ventricle, that is reduction in volume, regression of LV mass, improvement in ejection fraction and severity of mitral regurgitation induced by synchronization of ventricular contraction.
This new text is edited by 5 experts in heart failure, electrophysiology and non-invasive cardiac imaging and is extensively illustrated with high quality figures and examples of clinical cases. The purpose of the book is to put into perspective this novel therapy with regards to traditional heart failure treatment and to provide criteria for identifying patients likely to have an optimal and sustained response to CRT using a practical "how to" approach. This text begins by describing the background and evolution of the technique to the current implementation and the impact of complications on clinical outcome. There are chapters describing "cutting edge" Doppler echocardiography for assessing dyssynchrony, reverse remodeling and triaging patients into those with greatest likelihood of responding to CRT with illustrative clinical case examples. There is a full description of the results of all the randomized clinical trials and a number of chapters discussing the need for concomitant internal cardiac defibrillator (ICD), special circumstances such as atrial fibrillation, right bundle branch block, left ventricular lead placement and etiology of heart failure with clinical case examples for each.
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In recent decades, the prevalence of heart failure has steadily increased and can be considered a 'contemporary cardiovascular epidemic'. Therefore, treatment of heart failure is a primary focus of cardiovascular disease management strategies.
Cardiac Resynchronization Therapy provides basic knowledge about congestive heart failure but also covers the evolution of cardiac resynchronization therapy and provides state-of-the-art information and future directions of this therapeutic tool.
As CRT is a new therapy which still undergoes rapid advancement, it is imperative to provide updates in key issues. These include technological advances, the unique role of imaging to assess mechanical dyssynchrony, troubleshooting, recent key clinical trials, and the incorporation of monitoring capabilities into CRT or CRT plus defibrillation devices.
Cardiac Resynchronization Therapy is an essential addition to your collection.About the Author:
Cheuk-Man Yu, MBChB(CUHK), MRCP(UK), MD(CUHK), FHKCP, FHKAM(Medicine), FRACP, FRCP(Edin/London)
Professor, Head of Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital; and Clinical Director of Institute of Vascular Medicine, The Chinese University of Hong Kong, Hong Kong
David L. Hayes, MD
Chair, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic; and Professor of Medicine, Mayo College of Medicine, Rochester, MN, USA
Angelo Auricchio, MD, PhD
Associate Professor of Cardiology, University Hospital Magdeburg, Magdeburg, Germany; and Director Heart Failure Program, Fondazione Cardiocentro Ticino, Lugano, Switzerland
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