N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools (Catalysis Series, Volume 6) - Hardcover

Hardcover

ISBN 10: 1849730423 ISBN 13: 9781849730426

Publisher: Royal Society of Chemistry, 2010

Synopsis

Over the last fifteen years, N-heterocyclic carbenes (NHCs) have mostly been used as ancillary ligands for the preparation of transition metal-based catalysts. Compared to phosphorus-containing ligands, NHCs tend to bind more strongly to metal centres, avoiding the necessity for the use of excess ligand in catalytic reactions. The corresponding complexes are often less sensitive to air and moisture, and have proven remarkably resistant to oxidation. Recent developments in catalysis applications have been facilitated by the availability of carbenes stable enough to be bottled, particularly for their use as organocatalysts. This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium-catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Moreover, the biological activity of NHC-containing complexes, as well as an overview of their theoretical aspects are included. Such metal species are further examined, not only in terms of their catalytic applications, but also of their stereoelectronic parameters and reactivity/stability. Finally, special attention is given to the hot topic of organocatalysis. The book will be of interest to postgraduates, academic researchers and those working in industry.

About this title

Book Description

This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Such metal species are examined, not only in terms of their catalytic applications, but also their stereoelectronic parameters. Finally, special attention is given to the hot topic of organocatalysis. In this last chapter, particular emphasis is given to the novel reactivities being developed such as 1,2-additions, opening of small rings and O2 functionalization. The book will be of interest to postgraduates and those working in industry.

About the Author

Silvia Díez-González is a Senior Lecturer in the Department of Chemistry at Imperial College London, UK.

Edition details

• Publisher: Royal Society of Chemistry
• Publication date: 2010
• ISBN 10: 1849730423
• ISBN 13: 9781849730426
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 468
• Editor: Diez-Gonzalez Silvia