Extracellular Matrix Biology (Cold Spring Harbor Perspectives in Biology) - Hardcover

Hardcover

ISBN 10: 1936113384 ISBN 13: 9781936113385

Publisher: Cold Spring Harbor Laboratory Press, 2011

Synopsis

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.

Edition details

• Publisher: Cold Spring Harbor Laboratory Press
• Publication date: 2011
• ISBN 10: 1936113384
• ISBN 13: 9781936113385
• Binding: Hardcover
• Language: English
• Edition number: 1
• Number of pages: 397
• Editor: Hynes Richard O., Yamada Kenneth M.