The Endoplasmic Reticulum (Cold Spring Harbor Perspectives in Biology) - Hardcover

Ferro-Novick, Susan; Rapoport, Tom A.; Schekman, Randy

Hardcover

ISBN 10: 1936113821 ISBN 13: 9781936113828

Publisher: Cold Spring Harbor Laboratory Press, 2013

Synopsis

The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this volume covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed.

This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication. Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER.

About this title

About the Author

Susan Ferro-Novick is Distinguished Professor of Cellular and Molecular Medicine at the University of California, San Diego.

Edition details

• Publisher: Cold Spring Harbor Laboratory Press
• Publication date: 2013
• ISBN 10: 1936113821
• ISBN 13: 9781936113828
• Binding: Hardcover
• Language: English
• Number of pages: 336