Synopsis
The history of inhibitors of angiotensin converting enzyme.- Genetics of the renin-angiotensin-aldosterone system and risk of arterial disease.- Crosstalk between ACE inhibitors, B2 kinin receptor and nitric oxide in endothelial cells.- Interactions between the ACE and the endothelin pathway.- Evaluative and epidemiological approaches of ACE therapy.- The role of ACE inhibition in heart failure.- Angiotensin converting enzyme inhibition in the microcirculation.- Arterial structure and function and blockade of the reninangiotensin system in hypertension.- The contribution of angiotensin-converting enzyme (ACE) to the metabolism of kinins (bradykinin and des-Arg9-bradykinin) and effect of ACE inhibitors on their in vitro and in vivo metabolism.- Role of the renin-angiotensin system on the central and peripheral autonomic nervous system.- Dual inhibitors of angiotensin converting enzyme and neutral endopeptidase.- Pharmacodynamics, tissue-specificity of ACE inhibitors.- Effect of angiotensin converting enzyme inhibition on thirst and salt-appetite.- ACE and diabetes.
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