Bacterial And Eukaryotic Porins: Structure, Function, Mechanism - Hardcover

9783527307753: Bacterial And Eukaryotic Porins: Structure, Function, Mechanism

Hardcover

ISBN 10: 3527307753 ISBN 13: 9783527307753

Publisher: Vch Verlagsgesellschaft Mbh, 2004

This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice.
For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.
With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.

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From the Back Cover

For the first time, current knowledge on this important of proteins is now available in a single resource. This first book on porins in prokaryotes and eukaryotes relates the known physiological functions of porins to their molecular structure and mechanism. It brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.

From the contents:

Structure of Prokaryotic Porins
Functional Reconstitution of Porins
Regulation of Bacterial Porin Function
Role of Porins in Antibiotic Susceptibility
Drug Efflux and Protein Export through Porins
Structure and Function of Mitochondrial Porins
VDAC Function in Intracellular Signalling and Apoptosis

With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this important protein family.

About the Author

Roland Benz (born 1943) studied Mathematics, Chemistry and Physics at the University of W�rzburg (Germany) before joining the group of Peter L�uger at Konstanz University, where he obtained his PhD in Biology and his habilitation in Biophysics. Recipient of a Heisenberg Fellowship of the German Research Society (DFG), he was a Visiting Professor at the State University of New York in 1980 and again in 1982, and at the University of British Columbia in Vancouver in 1984. Since 1986 he is full Professor of Biotechnology at the University of W�rzburg. His research is centered on the molecular basis of membrane transport in microorganisms and higher organisms, with a special interest into pore-forming peptides and proteins.

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