Evolution of multiple alignments: Towards efficient data exploitation and knowledge extraction in the genomic era

 
9783639169324: Evolution of multiple alignments: Towards efficient data exploitation and knowledge extraction in the genomic era

Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies.

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About the Author:

Dr. Thompson is a bioinformatics researcher at the National Centre for Scientific Research (CNRS) in France. She received her BSc degree in Mathematics at Sheffield University, UK and her PhD at the Louis Pasteur University, Strasbourg, France.

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Thompson, Julie Dawn
ISBN 10: 3639169328 ISBN 13: 9783639169324
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Book Description Book Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | Towards efficient data exploitation and knowledge extraction in the genomic era | Genomics and proteomics technologies have led to aparadigm shift in bioinformatics, where thetraditional reductionist approach is replaced by amore global, integrated view. In this context,multiple sequence alignments provide an idealenvironment for the reliable integration ofinformation from a complete genome to a gene and itsrelated products. In this work, the sequence analysisfield is reviewed and three example developments aredescribed: (i) a benchmark for the objectiveevaluation of multiple alignment algorithms, (ii) amultiple alignment ontology (MAO) for nucleic acid orprotein sequences and structures, (iii) aninformation management system (MACSIMS) that exploitsthe multiple alignment and the organisation providedby the ontology. The work is central tobioinformatics today and should be particularlyuseful to researchers working in various fields, suchas genome analysis, target characterisation forstructural proteomics, the study of human geneticpathologies, or the development of new drug discoverystrategies. | Format: Paperback | Language/Sprache: english | 240 gr | 220x150x9 mm | 168 pp. Bookseller Inventory # K9783639169324

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Julie Dawn Thompson
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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Book Condition: Neu. 220x150x10 mm. Neuware - Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies. 168 pp. Englisch. Bookseller Inventory # 9783639169324

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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Book Condition: Neu. 220x150x10 mm. Neuware - Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies. 168 pp. Englisch. Bookseller Inventory # 9783639169324

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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Book Condition: Neu. 220x150x10 mm. This item is printed on demand - Print on Demand Neuware - Genomics and proteomics technologies have led to a 168 pp. Englisch. Bookseller Inventory # 9783639169324

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Book Description VDM Verlag, Russian Federation, 2012. Paperback. Book Condition: New. 220 x 150 mm. Language: English . Brand New Book. Genomics and proteomics technologies have led to a paradigm shift in bioinformatics, where the traditional reductionist approach is replaced by a more global, integrated view. In this context, multiple sequence alignments provide an ideal environment for the reliable integration of information from a complete genome to a gene and its related products. In this work, the sequence analysis field is reviewed and three example developments are described: (i) a benchmark for the objective evaluation of multiple alignment algorithms, (ii) a multiple alignment ontology (MAO) for nucleic acid or protein sequences and structures, (iii) an information management system (MACSIMS) that exploits the multiple alignment and the organisation provided by the ontology. The work is central to bioinformatics today and should be particularly useful to researchers working in various fields, such as genome analysis, target characterisation for structural proteomics, the study of human genetic pathologies, or the development of new drug discovery strategies. This book was created using print-on-demand technology. Bookseller Inventory # KNV9783639169324

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