Items related to Vesicular System Based Malaria Vaccine: A Novel Approach
The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphatidylcholine (EPC)and evaluated for intracellular cytosolic delivery of PfMSP-119 and as is evident from the results obtained; promising and significant immune responses were obtained by the cytosolic delivery of the malaria antigen through pH sensitive liposome. Moreover, after intramuscular immunization of PfMSP- 119 loaded pH sensitive liposomes, into Balb/c mice, the significant and perdurable IgG responses were obtained, as compared to conventional liposome loaded with PfMSP-119 and comparative evaluations have been marked with alum adsorbed malaria antigen. This may be attributed to good immuno-adjuvant action of pH sensitive liposomes, which are reported to enhance the immunogenicity of a soluble malaria antigen and present study might open new ways for the feasibility for the development of blood stage malaria vaccine.
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Rajesh Singh Jadon is a Assistant Professor of Pharmaceutical Biotechnology at Bansal College of Pharmacy, Bhopal. He received his M. Pharm from Dept of Pharmaceutical Sciences, Dr. HS Gour University, Sagar. He is member of international society for infectious diseases USA, Controlled Release Society-IC and indian immunology society.
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- PublisherVDM Verlag Dr. Müller
- Publication date2010
- ISBN 10 3639292790
- ISBN 13 9783639292794
- BindingPaperback
- Number of pages128
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Vesicular System Based Malaria Vaccine
Published by
VDM Verlag Dr. Müller
(2010)
ISBN 10: 3639292790
ISBN 13: 9783639292794
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphatidylcholine (EPC)and evaluated for intracellular cytosolic delivery of PfMSP-119 and as is evident from the results obtained; promising and significant immune responses were obtained by the cytosolic delivery of the malaria antigen through pH sensitive liposome. Moreover, after intramuscular immunization of PfMSP- 119 loaded pH sensitive liposomes, into Balb/c mice, the significant and perdurable IgG responses were obtained, as compared to conventional liposome loaded with PfMSP-119 and comparative evaluations have been marked with alum adsorbed malaria antigen. This may be attributed to good immuno-adjuvant action of pH sensitive liposomes, which are reported to enhance the immunogenicity of a soluble malaria antigen and present study might open new ways for the feasibility for the development of blood stage malaria vaccine. 128 pp. Englisch. Seller Inventory # 9783639292794
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Vesicular System Based Malaria Vaccine : A Novel Approach
Published by
VDM Verlag Dr. Müller
(2010)
ISBN 10: 3639292790
ISBN 13: 9783639292794
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphatidylcholine (EPC)and evaluated for intracellular cytosolic delivery of PfMSP-119 and as is evident from the results obtained; promising and significant immune responses were obtained by the cytosolic delivery of the malaria antigen through pH sensitive liposome. Moreover, after intramuscular immunization of PfMSP- 119 loaded pH sensitive liposomes, into Balb/c mice, the significant and perdurable IgG responses were obtained, as compared to conventional liposome loaded with PfMSP-119 and comparative evaluations have been marked with alum adsorbed malaria antigen. This may be attributed to good immuno-adjuvant action of pH sensitive liposomes, which are reported to enhance the immunogenicity of a soluble malaria antigen and present study might open new ways for the feasibility for the development of blood stage malaria vaccine. Seller Inventory # 9783639292794
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jadon Rajesh SinghRajesh Singh Jadon is a Assistant Professor of Pharmaceutical Biotechnology at Bansal College of Pharmacy, Bhopal. He received his M. Pharm from Dept of Pharmaceutical Sciences, Dr. HS Gour University, Sagar. He . Seller Inventory # 4974797
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Vesicular System Based Malaria Vaccine: A Novel Approach
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Book Description Paperback. Condition: Brand New. In Stock. Seller Inventory # zk3639292790
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