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The genesis of asymptomatic bacteriuria Escherichia coli strains: Evolution, bacterial genome plasticity and host-pathogen adaptations of asymptomatic bacteriuria (ABU) Escherichia coli strains - Softcover
Humans are home to so much wildlife, e.g. bacteria, which outnumber our cells by as many as 10 to 1. Here I discussed the evolution of asymptomatic bacteriuria (ABU), meaning colonization of the urinary tract without typical symptoms of a urinary tract infection (UTI). ABU isolates turned out to have remarkable genetic flexibility and often have no common progenitor. Reductive evolution by point mutations, DNA rearrangements and deletions resulted in inactivation of genes coding for several UTI-virulence factors. This supports the idea that a reduced bacterial activation of host mucosal inflammation promotes the ABU lifestyle, where gene regulation and genetic diversity enable bacteria to live and survive under continuously changing environmental conditions. I could demonstrate it here by employing human colonisation study, in which E. coli was exposed to different host backgrounds and adapt its colonisation strategy. This suggested that exposure of bacteria to the human immune response promotes genome plasticity thus being a driving force for the development of ABU and bacterial evolution within the urinary tract.
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Dr. Jaroslaw Zdziarski studied Biotechnology in Poland. In 2004, he joined The Graduate School of Live Sciences in Würzburg. After completing PhD, he continued research at the University of Würzburg working on bacterial genome dynamics and host-bacterium co-evolution. In 2010, he joined Biotech Company to develop techniques for pathogen detection.
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- PublisherVDM Verlag Dr. Müller
- Publication date2011
- ISBN 10 3639320573
- ISBN 13 9783639320572
- BindingPaperback
- Number of pages196
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The genesis of asymptomatic bacteriuria Escherichia coli strains: Evolution, bacterial genome plasticity and host-pathogen adaptations of asymptomatic bacteriuria (ABU) Escherichia coli strains
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Humans are home to so much wildlife, e.g. bacteria, which outnumber our cells by as many as 10 to 1. Here I discussed the evolution of asymptomatic bacteriuria (ABU), meaning colonization of the urinary tract without typical symptoms of a urinary tract infection (UTI). ABU isolates turned out to have remarkable genetic flexibility and often have no common progenitor. Reductive evolution by point mutations, DNA rearrangements and deletions resulted in inactivation of genes coding for several UTI-virulence factors. This supports the idea that a reduced bacterial activation of host mucosal inflammation promotes the ABU lifestyle, where gene regulation and genetic diversity enable bacteria to live and survive under continuously changing environmental conditions. I could demonstrate it here by employing human colonisation study, in which E. coli was exposed to different host backgrounds and adapt its colonisation strategy. This suggested that exposure of bacteria to the human immune response promotes genome plasticity thus being a driving force for the development of ABU and bacterial evolution within the urinary tract. 196 pp. Englisch. Seller Inventory # 9783639320572
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The genesis of asymptomatic bacteriuria Escherichia coli strains Evolution, bacterial genome plasticity and hostpathogen adaptations of asymptomatic bacteriuria ABU Escherichia coli strains
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Zdziarski JaroslawDr. Jaroslaw Zdziarski studied Biotechnology in Poland. In 2004, he joined The Graduate School of Live Sciences in Wuerzburg. After completing PhD, he continued research at the University of Wuerzburg working on bacte. Seller Inventory # 4977338
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The genesis of asymptomatic bacteriuria Escherichia coli strains : Evolution, bacterial genome plasticity and host-pathogen adaptations of asymptomatic bacteriuria (ABU) Escherichia coli strains
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VDM Verlag Dr. Müller
(2011)
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ISBN 13: 9783639320572
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Humans are home to so much wildlife, e.g. bacteria, which outnumber our cells by as many as 10 to 1. Here I discussed the evolution of asymptomatic bacteriuria (ABU), meaning colonization of the urinary tract without typical symptoms of a urinary tract infection (UTI). ABU isolates turned out to have remarkable genetic flexibility and often have no common progenitor. Reductive evolution by point mutations, DNA rearrangements and deletions resulted in inactivation of genes coding for several UTI-virulence factors. This supports the idea that a reduced bacterial activation of host mucosal inflammation promotes the ABU lifestyle, where gene regulation and genetic diversity enable bacteria to live and survive under continuously changing environmental conditions. I could demonstrate it here by employing human colonisation study, in which E. coli was exposed to different host backgrounds and adapt its colonisation strategy. This suggested that exposure of bacteria to the human immune response promotes genome plasticity thus being a driving force for the development of ABU and bacterial evolution within the urinary tract. Seller Inventory # 9783639320572
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The genesis of asymptomatic bacteriuria Escherichia coli strains Evolution, bacterial genome plasticity and hostpathogen adaptations of asymptomatic bacteriuria ABU Escherichia coli strains
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ISBN 13: 9783639320572
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