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Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs: Making medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry - Softcover
Synopsis
Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNA can act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits.
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About the Author
Dr. Gourishankar, Associate Professor, STES's SKNCOP, India, had received M.Pharm. (Pharm Chem.) and Ph.D. in Biotechnology (NCL-CSIR) from UoP, Pune. He was DBT-Post-Doc Fellow at NCBS-TIFR, India. His research has been supported by grants from DST & UoP and published in peer-reviewed journals. His research interest is in area of nanotherapeutics.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3659138509
- ISBN 13 9783659138508
- BindingPaperback
- LanguageEnglish
- Number of pages332
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Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs
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LAP LAMBERT Academic Publishing Jul 2012, 2012
ISBN 10: 3659138509
ISBN 13: 9783659138508
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNA can act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits. 332 pp. Englisch. Seller Inventory # 9783659138508
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Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs : Making medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659138509
ISBN 13: 9783659138508
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Taschenbuch
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Peptide nucleic acids are a new class of DNA analogues in which charged sugar-phosphate backbone of DNA is replaced by a neutral and achiral polyamide backbone. The monomeric unit consists of N-(2-aminoethyl) glycine units to which nucleobases are attached through a conformationally rigid, tertiary acetamide linker group. The design and facile synthesis of sterically constrained new analogs of PNA having gem-dimethyl substitutions on glycine is presented. They show a higher binding to DNA relative to that with isosequential RNA. This may be a structural consequence of sterically rigid gem-dimethyl group, imposing a pre-organized conformation favorable for complex formation with cDNA. In this regard, gem-dimethyl functionality need to be explored more by introducing in aminoethyl segment or aminoethyl and glycine, both segments. Also, significant stabilization of DNA:PNA hybrids occurs upon complexation with gold nanoparticles. It is shown here that the non-thiolic polyanionic DNA can act as a template for organizing lysine capped cationic gold nanoparticles into linear superstructures. These types of assemblies may have potential for creating nanowires and lithographic circuits. Seller Inventory # 9783659138508
Quantity: 1 available
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Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659138509
ISBN 13: 9783659138508
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Aland GourishankarDr. Gourishankar, Associate Professor, STES s SKNCOP, India, had received M.Pharm. (Pharm Chem.) and Ph.D. in Biotechnology (NCL-CSIR) from UoP, Pune. He was DBT-Post-Doc Fellow at NCBS-TIFR, India. His research has. Seller Inventory # 5134238
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Modified PNAs: Synthesis and Interaction Studies with DNA & AuNPs: Making medicines from peptide nucleic acids (PNAs) using bio-inspired chemistry
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659138509
ISBN 13: 9783659138508
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