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Sensitising cervix against cancer: Addition of gemcitabine to standard therapy in locally advanced cervical cancer: A randomized comparative study - Softcover
Synopsis
The concurrent Chemoradiotherapy for cervical cancer treatment is well accepted since 1999. This study was aimed to observe if any improved outcome could be obtained capitalizing on the synergistic activity of Gemcitabine, Cisplatin, XRT. Stage IIB-IIIB were randomized to control group and study group. Control group received Cisplatin 40 mg/m2 weekly with concurrent XRT, followed by brachytherapy and study group received Gemcitabine 125 mg/m2 weekly top of the same control group treatment. The primary end-point was pathological response and toxicities along with patient compliance to treatment, late reactions, DFS & OS in a scenario like our local community. The complete response was slightly better in study arm. Toxicities were significantly high in the study group compared to control group. The distant failure prevailed in control arm. On a median follow up of little less than two years, the DFS in study arm was slightly better than control arm. If the toxicity can be managed adequately in the combination chemo radiation group, it may produce an improvement in response. Survival benefit can also be obtained by introducing gemcitabine to cisplatin as radio sensitizer.
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About the Author
Dr. Sanjoy Roy has been trained in Radiation Oncology from C.N.C.I and is attached with the department since 2006. His area of interest is Cervical cancer and Breast conservation. Currently he is involved in Conformal Therapy delivery technique in Cervical Cancer and also delivers training & guidance to DNB PG trainees.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3659146692
- ISBN 13 9783659146695
- BindingPaperback
- Number of pages76
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Sensitising cervix against cancer: Addition of gemcitabine to standard therapy in locally advanced cervical cancer: A randomized comparative study
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Sensitising cervix against cancer
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The concurrent Chemoradiotherapy for cervical cancer treatment is well accepted since 1999. This study was aimed to observe if any improved outcome could be obtained capitalizing on the synergistic activity of Gemcitabine, Cisplatin, XRT. Stage IIB-IIIB were randomized to control group and study group. Control group received Cisplatin 40 mg/m2 weekly with concurrent XRT, followed by brachytherapy and study group received Gemcitabine 125 mg/m2 weekly top of the same control group treatment. The primary end-point was pathological response and toxicities along with patient compliance to treatment, late reactions, DFS & OS in a scenario like our local community. The complete response was slightly better in study arm. Toxicities were significantly high in the study group compared to control group. The distant failure prevailed in control arm. On a median follow up of little less than two years, the DFS in study arm was slightly better than control arm. If the toxicity can be managed adequately in the combination chemo radiation group, it may produce an improvement in response. Survival benefit can also be obtained by introducing gemcitabine to cisplatin as radio sensitizer. 76 pp. Englisch. Seller Inventory # 9783659146695
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Sensitising cervix against cancer : Addition of gemcitabine to standard therapy in locally advanced cervical cancer: A randomized comparative study
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The concurrent Chemoradiotherapy for cervical cancer treatment is well accepted since 1999. This study was aimed to observe if any improved outcome could be obtained capitalizing on the synergistic activity of Gemcitabine, Cisplatin, XRT. Stage IIB-IIIB were randomized to control group and study group. Control group received Cisplatin 40 mg/m2 weekly with concurrent XRT, followed by brachytherapy and study group received Gemcitabine 125 mg/m2 weekly top of the same control group treatment. The primary end-point was pathological response and toxicities along with patient compliance to treatment, late reactions, DFS & OS in a scenario like our local community. The complete response was slightly better in study arm. Toxicities were significantly high in the study group compared to control group. The distant failure prevailed in control arm. On a median follow up of little less than two years, the DFS in study arm was slightly better than control arm. If the toxicity can be managed adequately in the combination chemo radiation group, it may produce an improvement in response. Survival benefit can also be obtained by introducing gemcitabine to cisplatin as radio sensitizer. Seller Inventory # 9783659146695
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Sensitising cervix against cancer
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Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Roy SanjoyDr. Sanjoy Roy has been trained in Radiation Oncology from C.N.C.I and is attached with the department since 2006. His area of interest is Cervical cancer and Breast conservation. Currently he is involved in Conformal Thera. Seller Inventory # 5134864
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Sensitising cervix against cancer: Addition of gemcitabine to standard therapy in locally advanced cervical cancer: A randomized comparative study
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