Exon Intron Sequence Prediction: Using Chaos Game Representation - Softcover

Boniface, P. J.

Softcover

ISBN 10: 3659165093 ISBN 13: 9783659165092

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Research into new methods to identify genes in genomic sequences has been going on for more than 20 years. Computational methods are indeed very useful in gene identification within the area of Bioinformatics. Here a new method has been developed to predict whether the sequence given is exon or intron. The chaos game representation (CGR) is a novel way of revealing patterns within nucleotide sequences . The CGR representation is done using a square scatter plot with one of the bases A, G, C and T at different corners of the square. Here scatter plots, Quadrilateral pattern (measuring area and angle at right bottom), sixteen quadrant (mesh) plot, sixty four quadrant plots and patterns using sliding window method are generated to identify whether a given sequence represents Exon or Intron. The quadrilateral pattern shows significant variation between Exon and Intron sequences based on which an algorithm has been developed for testing the sequence. The algorithm developed performs with a percentage of 72.09 accuracy while testing different sequences.

About this title

About the Author

P.J. Boniface has been working as Faculty in Computer Science at Kerala Agricultural University since 16 years. Currently he is Associate Professor in the College of Co-operation, Banking and Management. Ha has many research papers and one book at his credit.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659165093
• ISBN 13: 9783659165092
• Binding: Paperback
• Number of pages: 132