Polydnavirus Histone H4 and its role in insect immunity: Polydnavirus Histone H4 - Softcover

Gad, Wael; Kim, Yonggyun

 
9783659243981: Polydnavirus Histone H4 and its role in insect immunity: Polydnavirus Histone H4
Softcover
ISBN 10: 3659243981 ISBN 13: 9783659243981
Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Cotesia plutellae (Braconidae: Hymenoptera) is a solitary endoparasitoid wasp that parasitizes the diamondback moth, Plutella xylostella (L.) (Yponomeutidae: Lepidoptera). For successful parasitization, its symbiotic polydnavirus (CpBV) helps the wasps to attenuate host immune capacity and manipulate host developmental physiology. An analysis of CpBV genome sequence indicated the presence of one putative gene (CpBV-H4) showing a high similarity to histone H4. Histone H4, one of the four histone subunits along with H2A, H2B and H3, forms an eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. CpBV-H4 showed expression in different tissues in parasitized P. xylostella. Transient expression of CpBV-H4 in nonparasitized P. xylostella resulted in significant impairment of hemocyte-spreading and decreased gene expression of host H4, while knock-down of the transient expression using double-stranded RNA interference recovered the immune capacity and gene expression.

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About the Author

Wael Gad is PhD Researcher, Department of Structure Biology at Vrije University Brussels. Master of Science, Department of Bioresource Sciences, Andong National University, South Korea. B.Sc. of Zoology, Department of Zoology and Marine Biology, Al-Azhar University Assiut, Egypt.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2012
Language
English
ISBN 10 
3659243981
ISBN 13 
9783659243981
Binding
Paperback
Number of pages
88