Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release - Softcover
Synopsis
The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.
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About the Author
The author is Vikas Kumar Srivastava S/o late Om Prakash Srivastava, have completed his B.Pharm (2006-2010) from LIMT, Gr. Noida with 81%. He had completed M.Pharma (Pharmaceutics) from I.T.S Paramedical (Pharmacy) college, Ghaziabad, affiliated to Maha Maya Technical University, Noida. He had published many review and research articles.
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Dissolution Enhancement Using Different Formulation Approaches
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ISBN 13: 9783659453359
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products. 144 pp. Englisch. Seller Inventory # 9783659453359
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Dissolution Enhancement Using Different Formulation.
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Dissolution Enhancement Using Different Formulation Approaches
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Srivastava Vikas KumarThe author is Vikas Kumar Srivastava S/o late Om Prakash Srivastava, have completed his B.Pharm (2006-2010) from LIMT, Gr. Noida with 81%. He had completed M.Pharma (Pharmaceutics) from I.T.S Paramedical (Pharma. Seller Inventory # 5157073
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Dissolution Enhancement Using Different Formulation Approaches
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 144 pp. Englisch. Seller Inventory # 9783659453359
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Dissolution Enhancement Using Different Formulation Approaches | Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release
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Taschenbuch. Condition: Neu. Dissolution Enhancement Using Different Formulation Approaches | Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release | Vikas Kumar Srivastava (u. a.) | Taschenbuch | 144 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659453359 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 105618249
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Dissolution Enhancement Using Different Formulation Approaches : Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release
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ISBN 13: 9783659453359
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products. Seller Inventory # 9783659453359
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Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement Of A Poorly Soluble Model Drugs Using Different Formulation Approaches For Immediate Release
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Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release
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ISBN 13: 9783659453359
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