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A new biolistic gene gun for micromolecular drug delivery to human skin has been developed and numerically tested. The device generates supersonic flow to accelerate the mediated microparticles to sufficient speeds to breach the outer human skin layer. The device is referred to as CDN-WPI and consists of; a high pressure gas tank, a convergent-divergent nozzle (C-D), and a constant area mixing duct. The mediated microparticles are entrained from a parallel inlet after the exit of the C-D nozzle. The gas from the high pressure tank accelerates through the C-D nozzle to supersonic speeds which in turn accelerate the powder microparticles through the constant area mixing duct to high speeds. A validated numerical procedure is used to study the two-phase flow dynamics inside the biolistic gun using different geometrical configurations. Different driver gas pressures, gas type (helium and air), adding gas swirl, microparticles types and size are considered in this study. The dimensions of the device C-D nozzle, mixing duct length, and the number of particles inlets are the geometrical configurations studied.
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- PublisherLAP Lambert Academic Publishing
- Publication date2014
- ISBN 10 3659638196
- ISBN 13 9783659638190
- BindingPaperback
- Number of pages164
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Micro-Particles and Gas Dynamics in an Axi-Symmetric Supersonic Nozzle
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Micro-Particles and Gas Dynamics in an Axi-Symmetric Supersonic Nozzle
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A new biolistic gene gun for micromolecular drug delivery to human skin has been developed and numerically tested. The device generates supersonic flow to accelerate the mediated microparticles to sufficient speeds to breach the outer human skin layer. The device is referred to as CDN-WPI and consists of; a high pressure gas tank, a convergent-divergent nozzle (C-D), and a constant area mixing duct. The mediated microparticles are entrained from a parallel inlet after the exit of the C-D nozzle. The gas from the high pressure tank accelerates through the C-D nozzle to supersonic speeds which in turn accelerate the powder microparticles through the constant area mixing duct to high speeds. A validated numerical procedure is used to study the two-phase flow dynamics inside the biolistic gun using different geometrical configurations. Different driver gas pressures, gas type (helium and air), adding gas swirl, microparticles types and size are considered in this study. The dimensions of the device C-D nozzle, mixing duct length, and the number of particles inlets are the geometrical configurations studied. 164 pp. Englisch. Seller Inventory # 9783659638190
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Micro-Particles and Gas Dynamics in an Axi-Symmetric Supersonic Nozzle
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - A new biolistic gene gun for micromolecular drug delivery to human skin has been developed and numerically tested. The device generates supersonic flow to accelerate the mediated microparticles to sufficient speeds to breach the outer human skin layer. The device is referred to as CDN-WPI and consists of; a high pressure gas tank, a convergent-divergent nozzle (C-D), and a constant area mixing duct. The mediated microparticles are entrained from a parallel inlet after the exit of the C-D nozzle. The gas from the high pressure tank accelerates through the C-D nozzle to supersonic speeds which in turn accelerate the powder microparticles through the constant area mixing duct to high speeds. A validated numerical procedure is used to study the two-phase flow dynamics inside the biolistic gun using different geometrical configurations. Different driver gas pressures, gas type (helium and air), adding gas swirl, microparticles types and size are considered in this study. The dimensions of the device C-D nozzle, mixing duct length, and the number of particles inlets are the geometrical configurations studied. Seller Inventory # 9783659638190
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MicroParticles and Gas Dynamics in an AxiSymmetric Supersonic Nozzle
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Book Description PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L0-9783659638190
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Micro-Particles and Gas Dynamics in an Axi-Symmetric Supersonic Nozzle
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Abdallah ShaabanShaaban Abdallah, Professor,Department of Aerospace Engineering, University of Cincinnati. Salah Soliman, Research Scientist, Technical Research Center, EgyptA new biolistic gene gun for micromolecular drug delive. Seller Inventory # 5170211
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