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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability: Formulation and In-vitro / In-vivo Evaluation - Softcover

Aly Kassem, Mohamed; Nabil El-Meshad, Aliaa

 
9783659665936: Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability: Formulation and In-vitro / In-vivo Evaluation
Softcover
ISBN 10: 3659665932 ISBN 13: 9783659665936
Publisher: LAP LAMBERT Academic Publishing, 2014
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Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half–life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product.

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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half-life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product. 328 pp. Englisch. Seller Inventory # 9783659665936

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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Roshdy Fares AhmedAhmed Roshdy Fares, MSc. Teaching and research assistant in Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy - Cairo university. Earned a Master degree in Pharmaceutical Sciences.Buccal deli. Seller Inventory # 5171312

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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half-life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product. Seller Inventory # 9783659665936

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