Items related to Scientific Issues in Quantitative Cancer Risk Assessment
Synopsis
The Clonogenic Cells of the Rat Mammary and Thyroid Their Biology, Frequency of Initiation, and Promotion/Progression to Cancer.- The Somatic Mutational Component of Human Carcinogenesis.- Two-Event Roles of Oncogenes and Antioncogenes.- Genetic Alterations during Carcinogenesis in Implications for Cancer Risk Assessment.- Multistage Hepatocarcinogenesis in the Rat as a Basis for Models of Risk Assessment of Carcinogenesis.- Cell Proliferation and Hepatocarcinogenesis.- Cell Growth Dynamics and DNA Alterations in Carcinogenesis.- Two Mutation Model for Relative Roles of Somatic Mutations and Cell Proliferation in Determining Risk.- Cancer Dose-Response Models Incorporating Clonal Expansion.- Transformation and Growth of Lung Adenomas in Mice Exposed to Urethane.- Cancer Modeling with Intermittent Exposures.- Possible Role of Selective Gap Junctional Intercellular Communication in Multistage Carcinogenesis.- Interindividual Variation in Human Chemical Implications for Risk Assessment.- Utilizing Biologically Based Models to Estimate Carcinogenic Risk.- Variability of Unit Risk Estimates under Different Statistical Models and between Different Epidemiological Data Sets.- Carcinogenic A Model Data-base for Human Risk Quantification.- Some Thoughts on What Was Learned and Some Science Policy Issues.
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