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Modulation of actin dynamics by the S.pneumoniae toxin pneumolysin: A novel mechanism beyond pore formation - Softcover
Synopsis
The pneumococcus is one major cause of bacterial meningitis, a wide-spread disease of newborn and immune-compromised individuals, which shows CFRs up to 50% in countries with low medical standards. Bacterial spreading affects the meninges, and the sub-meningeal cortex tissue, whereat the presence of pneumolysin, a major virulence factor of the pneumococcus, is prerequisite for the development of a severe outcome of the infection and associated tissue damage. Pneumolysin belongs to the family of cholesterol-dependent cytolysins, which use membrane-cholesterol as receptor and oligomerize to big aggregates, which induce cell lysis and cell death by disturbance of membrane integrity. This work has revealed a new picture of pneumolysin, whose cell-related properties go beyond pore formation and cell lysis. A direct interaction of the toxin with actin leads to cell-shape remodeling in astrocytes, which potentially disturbes neuronal homeostasis and favors bacterial tissue penetration.
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About the Author
Sabrina Hupp (Dipl Biol Univ). Master of Science in Biology (Microbiology, Forensic Medicine and Pharmaceutical Biology) at the University of Würzburg. PhD, Biomedical Science Graduate Program at the University of Würzburg (Rudolf-Virchow-Center, DFG Research Center for Experimental Biomedicine).
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- PublisherSüdwestdeutscher Verlag für Hochschulschriften
- Publication date2012
- ISBN 10 3838109910
- ISBN 13 9783838109916
- BindingPaperback
- LanguageEnglish
- Number of pages152
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Modulation of actin dynamics by the S.pneumoniae toxin pneumolysin
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Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jul 2015, 2015
ISBN 10: 3838109910
ISBN 13: 9783838109916
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The pneumococcus is one major cause of bacterial meningitis, a wide-spread disease of newborn and immune-compromised individuals, which shows CFRs up to 50% in countries with low medical standards. Bacterial spreading affects the meninges, and the sub-meningeal cortex tissue, whereat the presence of pneumolysin, a major virulence factor of the pneumococcus, is prerequisite for the development of a severe outcome of the infection and associated tissue damage. Pneumolysin belongs to the family of cholesterol-dependent cytolysins, which use membrane-cholesterol as receptor and oligomerize to big aggregates, which induce cell lysis and cell death by disturbance of membrane integrity. This work has revealed a new picture of pneumolysin, whose cell-related properties go beyond pore formation and cell lysis. A direct interaction of the toxin with actin leads to cell-shape remodeling in astrocytes, which potentially disturbes neuronal homeostasis and favors bacterial tissue penetration. 152 pp. Englisch. Seller Inventory # 9783838109916
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Modulation of actin dynamics by the S.pneumoniae toxin pneumolysin : A novel mechanism beyond pore formation
Published by
Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG, 2012
ISBN 10: 3838109910
ISBN 13: 9783838109916
New
Taschenbuch
Seller: AHA-BUCH GmbH, Einbeck, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The pneumococcus is one major cause of bacterial meningitis, a wide-spread disease of newborn and immune-compromised individuals, which shows CFRs up to 50% in countries with low medical standards. Bacterial spreading affects the meninges, and the sub-meningeal cortex tissue, whereat the presence of pneumolysin, a major virulence factor of the pneumococcus, is prerequisite for the development of a severe outcome of the infection and associated tissue damage. Pneumolysin belongs to the family of cholesterol-dependent cytolysins, which use membrane-cholesterol as receptor and oligomerize to big aggregates, which induce cell lysis and cell death by disturbance of membrane integrity. This work has revealed a new picture of pneumolysin, whose cell-related properties go beyond pore formation and cell lysis. A direct interaction of the toxin with actin leads to cell-shape remodeling in astrocytes, which potentially disturbes neuronal homeostasis and favors bacterial tissue penetration. Seller Inventory # 9783838109916
Quantity: 1 available
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Modulation of actin dynamics by the S.pneumoniae toxin pneumolysin
Published by
Südwestdeutscher Verlag für Hochschulschriften, 2012
ISBN 10: 3838109910
ISBN 13: 9783838109916
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Seller: moluna, Greven, Germany
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Hupp SabrinaSabrina Hupp (Dipl Biol Univ). Master of Science in Biology (Microbiology, Forensic Medicine and Pharmaceutical Biology) at the University of Wuerzburg. PhD, Biomedical Science Graduate Program at the University of Wuerzbur. Seller Inventory # 5405375
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