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Synopsis
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures.
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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LAP LAMBERT Academic Publishing Feb 2010, 2010
ISBN 10: 3838346149
ISBN 13: 9783838346144
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures. 124 pp. Englisch. Seller Inventory # 9783838346144
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
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Condition: New. Print on Demand pp. 124 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. Seller Inventory # 131703732
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Kristoffersen KarinaCurrent position: PhD student. Copenhagen National University Hospital, Denmark. | Education: MSc in Human Biology. University of Copenhagen, Denmark. May 2009. BSc in Biology-Biotechnology, University of Copen. Seller Inventory # 5415057
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2010
ISBN 10: 3838346149
ISBN 13: 9783838346144
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
Published by
LAP LAMBERT Academic Publishing Feb 2010, 2010
ISBN 10: 3838346149
ISBN 13: 9783838346144
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 124 pp. Englisch. Seller Inventory # 9783838346144
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
Published by
LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838346149
ISBN 13: 9783838346144
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures. Seller Inventory # 9783838346144
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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
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LAP LAMBERT Academic Publishing, 2010
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ISBN 13: 9783838346144
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Taschenbuch. Condition: Neu. A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells | Karina Kristoffersen | Taschenbuch | 124 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838346144 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Seller Inventory # 101291303
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