Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends: Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)" - Softcover
Synopsis
The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using "Design of Experiments". A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the "optimized" formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels.
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About the Author
Dr Bhupinder Singh Bhoop, Prof and Dean at Panjab University, India, is globally acclaimed for drug delivery. He has to his credit 110 publications, 7 book chapters, 4 patents and 13 research projects. He has delivered over 100 talks and presented 130 papers the world over. On Editorial Board of 12 journals, he has received several awards too.
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends
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LAP LAMBERT Academic Publishing Sep 2010, 2010
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ISBN 13: 9783838394251
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using 'Design of Experiments'. A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the 'optimized' formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels. 248 pp. Englisch. Seller Inventory # 9783838394251
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh BhupinderDr Bhupinder Singh Bhoop, Prof and Dean at Panjab University, India, is globally acclaimed for drug delivery. He has to his credit 110 publications, 7 book chapters, 4 patents and 13 research projects. He has delive. Seller Inventory # 5419650
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends | Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)"
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ISBN 10: 3838394259
ISBN 13: 9783838394251
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Taschenbuch. Condition: Neu. Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends | Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)" | Bhupinder Singh (u. a.) | Taschenbuch | 248 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838394251 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 107304503
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends
Published by
LAP LAMBERT Academic Publishing Sep 2010, 2010
ISBN 10: 3838394259
ISBN 13: 9783838394251
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using 'Design of Experiments'. A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the 'optimized' formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 248 pp. Englisch. Seller Inventory # 9783838394251
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends : Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)"
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LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838394259
ISBN 13: 9783838394251
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using 'Design of Experiments'. A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the 'optimized' formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels. Seller Inventory # 9783838394251
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Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends: Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)"
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ISBN 13: 9783838394251
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